3D printing of patient-specific implants for osteochondral defects: workflow for an MRI-guided zonal design
نویسندگان
چکیده
Abstract Magnetic resonance imaging (MRI) is a common clinical practice to visualize defects and distinguish different tissue types pathologies in the human body. So far, MRI data have not been used model generate patient-specific design of multilayered substitutes case interfacial defects. For orthopedic cases that require highly individual surgical treatment, implant fabrication by additive manufacturing holds great potential. Extrusion-based techniques like 3D plotting allow spatially defined application several materials, as well implementation bioprinting strategies. With example typical multi-zonal osteochondral defect an osteochondritis dissecans (OCD) patient, this study aimed close technological gap between analysis process based on biomaterial inks. A workflow was developed which covers processing steps MRI-based identification, segmentation, modeling, adjustment, generation. fabricated two inks with clinically relevant properties would for bioprinting, direct embedding patient’s own cells printing process. As demonstrated geometric compatibility designed stereolithography (SLA) lesioned femoral condyles, novel versatile CAD/CAM successfully established opens up new perspectives treatment (osteochondral) Graphic abstract
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ژورنال
عنوان ژورنال: Bio-design and manufacturing
سال: 2021
ISSN: ['2096-5524', '2522-8552']
DOI: https://doi.org/10.1007/s42242-021-00153-4